In 2005, Brian Brohm passed for 2,883 yards and 19 touchdowns before suffering a season-ending knee injury in a game against Syracuse on November 25, 2005. He was forced to miss Louisville's last regular season game, a December 2 match-up against Connecticut, and was still in rehabilitation when the Cardinals lost to Virginia Tech in the 2006 Gator Bowl.

Brian Brohm was drafted in the MLB draft following his senior year in high school. Brian's brother Jeff was also drafted out of high school and played in minor leagues during the summers of his college career.

Brohm announced his decision to attend the University of Louisville on January 20, 2004, picking the hometown Cardinals over scholarship offers from the University of Kentucky, Notre Dame, Tennessee, Alabama, Nebraska, Purdue, Illinois and others. Brohm enrolled at Louisville in the fall of 2004 and immediately began competing for the starting quarterback spot with Stefan LeFors.

His first season, Brohm was named Conference USA Freshman of the Year, despite not starting a single game. Brohm completed 66 of 98 passes for 819 yards and six touchdowns. After entering the game for at least one series per game as a true freshman, Brohm followed in the footsteps of father, Oscar, and brother, Jeff, by becoming a starting quarterback at the University of Louisville in 2005. His brother, Greg, also played at Louisville as a receiver.

In 2005, Brohm passed for 2,883 yards and 19 touchdowns before suffering a season-ending knee injury in a game against Syracuse on November 25. He was forced to miss Louisville's last regular season game, a December 2 matchup against Connecticut, and was still in rehabilitation when the Cardinals lost to Virginia Tech in the 2006 Gator Bowl.

Brohm injured his thumb in Louisville's September 16, 2006 victory over the Miami Hurricanes. He returned as starting quarterback in Louisville's October 14, 2006 victory against Cincinnati. He had been replaced at starting quarterback by sophomore backup Hunter Cantwell for the previous two games. Before his injury, Brohm was one of two candidates at U of L for the 2006 Heisman Trophy, along with senior running back Michael Bush. The pair, both born and raised in Louisville, were dubbed "The Derby City Duo."

In the 2007 Orange Bowl, Brohm earned MVP honors by leading Louisville to its first ever BCS victory, 24-13 over Wake Forest. Brohm completed 24 of 34 passes for 311 yards, the third highest total in Orange Bowl history.

Though The Sporting News projected Brohm as high as the top pick in the 2007 NFL draft , and many other experts had projected him as going no later than the first round, Brohm announced on January 15, 2007, after a long period of speculation, that he would return to the University of Louisville for his senior year.

After the 2007 Orange Bowl, he stated that "Right now, coming back and trying to win a national title looks very appealing." Almost all analysts believe that Brohm has NFL talent, however they disagree about his draft status and whether he should have stayed for his senior season. Following the announcement of his now former head coach Bobby Petrino as new head coach of the Atlanta Falcons, further speculation occurred that Brohm might skip his senior season, which would inevitably be under a new head coach, and enter the draft.

The fact that the 2008 draft is infused with top-prospect quarterbacks whose playing styles are very similar to Brohm's (most notably Kentucky's Andre Woodson, Michigan's Chad Henne, USC's John David Booty, Penn State's Anthony Morelli, Hawaii's Colt Brennan, and Tennessee's Erik Ainge) was also a key argument for Brohm's possible entry in the 2007 draft, where the other first round-bound quarterbacks include the more diverse characters of Brady Quinn and JaMarcus Russell. However, Brohm eventually decided to pass up the potential millions he could earn from the NFL, and instead chose to return for his senior season for another shot at helping the Cardinals to a BCS National Championship. Brohm will have to learn the new offense from the new head coach Steve Kragthorpe, who previously coached at the University of Tulsa. However, ESPN is ranking Brohm as the #1 senior in the '08 draft class, saying his "big arm, prototypical size, quick release, [and] expert touch" help him stand out.

Brohm scored a 32 on the Wonderlic exam out of the 50 questions, tying Matt Ryan for the highest score among quarterbacks. Brohm and Ryan handily beat the average QB score of 24, and their score indicates an estimated IQ of 124.

Green Bay Packers
Brohm was drafted by the Green Bay Packers in the second round of the 2008 NFL Draft. He was the 56th player taken overall. Aaron Rodgers is expected to start at quarterback for the Packers, making Brohm the likely backup.

Topps 2008 NFL Rookie Photo Shoot with Brian Brohm