LOUISVILLE, Ky. (AP) -- Syracuse wide receiver Taj Smith stood all alone at midfield waving his arms, surprised by how wide open he was.

It's become a familiar feeling for Louisville opponents this season.

Smith hauled in the pass from quarterback Andrew Robinson and raced 79 yards for a touchdown on the game's first play, and the Orange were on the way to a 38-35 upset over the defenseless Cardinals on Saturday.

"Louisville is a powerhouse offense, but we felt like we could do it too," Smith said. "I just kept telling them "Keep it going.""

Smith later added a 60-yard touchdown reception, finishing with four receptions for 173 yards as the Orange (1-3, 1-0 Big East) ended the nation's second-longest home winning streak at 20.

"We were rolling on all four cylinders," defensive end Jameel McClain said. "I don't know if they were ripe for an upset. You can look at it as an upset, but I don't."

This was no lucky last-minute stunner. The Orange led throughout behind Robinson, who threw for a career-high 423 yards and tied a school record with four touchdowns.

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