TAMPA, Fla. (AP) -- Louisville's potent offense was no match for South Florida's tenacious defense.

Mike Ford rushed for 140 yards and two touchdowns and USF forced seven turnovers while holding Brian Brohm to a season-low passing total as the Bulls manhandled the Cardinals 55-17 on Saturday night.

Brian Brohm was intercepted three times and his backup, Hunter Cantwell, was picked off once. The Cardinals also lost three fumbles while being held to 405 yards, well below their Big East-leading season average of 497.6 per game.

Louisville (5-6, 2-4) turned the ball over on the opening kickoff and never recovered.

Trent Guy fumbled returning the kick, USF's Nate Allen picked up the loose ball at the Cardinals 3 and continued into the end zone, a place the Bulls would visit five more times in the first half alone.

USF (8-3, 3-3) also scored on Trae Williams' 64-yard interception return and Ford's 6-yard TD that capped an 89-yard drive in which the freshman tailback also ran for 43 and 23 yards on consecutive plays.

Ford carried 24 times a week after p